She Blinded Me With Science

This 1982 new wave single by Thomas Dolby and Tim Kerr peaked at number 5 on the Billboard Hot 100 and spent 2 weeks at number 1 in Canada, though it only reached number 49 in Dolby's native UK. VH1 later named it number 20 on its list of the "100 Greatest One-hit Wonders" in 2002 and number 76 on "Greatest Songs of the '80s" in 2006, and the song was used as the theme in the pilot episode of The Big Bang Theory.